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KMID : 1137020080190010075
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Journal of Gynecologic Oncology
2008 Volume.19 No. 1 p.75 ~ p.80
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Clinical analysis for the prognostic factors in patients with recurrent epithelial ovarian cancer who underwent secondary cytoreductive surgery
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Kim Hee-Seoung
Kim Tae-Hun
Chung Hyun-Hoon
Kim Jae-Won
Park Noh-Hyun
Song Yong-Sang
Kang Soon-Beom
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Abstract
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Objective : To identify clinical prognostic factor improving survival of recurrent epithelial ovarian cancer (EOC) patients treated with secondary cytoreductive surgery (SCS).
Methods : The indications of SCS were as follows; 1) complete response (CR) after primary cytoreductive surgery and adjuvant chemotherapy, 2) disease-free survival (DFS) (≥6 months). Clinical data of 17 patients including age, DFS, peritoneal seeding identified during SCS, the number of recurrent tumors (≥1 cm), serum CA-125 levels and maximal diameter of residual tumor after SCS were reviewed retrospectively between January 1990 and March 2007. Survival analyses were performed using Kaplan-Meier method with log-rank test and univariate Cox’s regression analysis.
Results : Mean age of them was 51.7 years. No peritoneal seeding identified during SCS was a prognostic factor
improving progression-free survival after SCS (PFS-SCS) (30 vs. 6 months, p＜.01 hazard ratio 0.099, 95% confidence
interval 0.011-0.929, p=.043). Furthermore, serum CA-125 level (≤37 U/ml) after SCS was a significant prognostic factors
improving overall survival (51 vs. 19 months, p=.033; hazard ratio 0.212, 95% confidence interval 0.045-0.983, p=.045).
Conclusion : Serum CA-125 levels with normal value after SCS and no peritoneal seeding may be associated with the improvement of survival in recurrent epithelial ovarian cancer patients treated with SCS.
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KEYWORD
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Secondary cytoreductive surgery, Prognostic factor, Recurrent, Epithelial ovarian cancer
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